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KMID : 1134120210240060554
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Journal of Breast Cancer
2021 Volume.24 No. 6 p.554 ~ p.560
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Imaging Protocol and Criteria for Evaluation of Axillary Lymph Nodes in the NAUTILUS Trial
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Chang Jung-Min
Shin Hee-Jung
Choi Ji-Soo
Shin Sung-Ui
Choi Bo-Hwa
Kim Min-Jung
Yoon Jung-Hyun
Chung Jin
Kim Tae-Hee
Han Boo-Kyung
Kim Hak-Hee
Moon Woo-Kyung
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Abstract
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Axillary ultrasonography (US) is the most commonly used imaging modality for nodal evaluation in patients with breast cancer. No Axillary Surgical Treatment in Clinically Lymph Node-Negative Patients after Ultrasonography (NAUTILUS) is a prospective, multicenter, randomized controlled trial investigating whether sentinel lymph node biopsy (SLNB) can be safely omitted in patients with clinically and sonographically node-negative T1?2 breast cancer treated with breast-conserving therapy. In this trial, a standardized imaging protocol and criteria were established for the evaluation of axillary lymph nodes. Women lacking palpable lymph nodes underwent axillary US to dismiss suspicious nodal involvement. Patients with a round hypoechoic node with effaced hilum or indistinct margins were excluded. Patients with T1 tumors and a single node with a cortical thickness ≥ 3 mm underwent US-guided biopsy. Finally, patients with negative axillary US findings were included. The NAUTILUS axillary US nodal assessment criteria facilitate the proper selection of candidates who can omit SLNB.
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KEYWORD
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Breast Neoplasms, Sentinel Lymph Node Biopsy, Ultrasonography
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